Targeting glucose metabolism for cancer therapy

Targeting glucose metabolism for cancer therapy

Cellular transformation is associated with the reprogramming of cellular pathways that control proliferation, survival, and metabolism. Among the metabolic changes exhibited by tumor cells is an increase in glucose metabolism and glucose dependence. It has been hypothesized that targeting glucose metabolism may provide a selective mechanism by which to kill cancer cells. In this minireview, we ...

Targeting glucose metabolism in patients with cancer.

Nearly a century ago, Otto Warburg made the astute observation that the metabolic properties of cancer cells differ markedly from those of normal cells. Several decades passed before the concept of exploiting cancer cell metabolism came into clinical practice with the advent of chemotherapy, the underlying principle of which is to target rapidly dividing cells by interfering with critical proce...

Challenges in targeting cancer metabolism for cancer therapy.

A tumour is clonogenic in origin, dividing and accumulating accidental mutations over time to become a complex, heterogeneous mix of cells. By the time it is diagnosed, a typical tumour mass contains 30–80 somatic mutations [1]. This heterogeneity makes it difficult to eliminate all cancerous cells simultaneously by targeting mutated gene products [2], and we believe that even a single cancer c...

Editorial: Cancer Metabolism: Molecular Targeting and Implications for Therapy

Targeting glucose metabolism for healthy aging

Advancing age is the greatest single risk factor for numerous chronic diseases. Thus, the ability to target the aging process can facilitate improved healthspan and potentially lifespan. Lack of adequate glucoregulatory control remains a recurrent theme accompanying aging and chronic disease, while numerous longevity interventions result in maintenance of glucoregulatory control. In this review...